Impact of severe obesity in the management of patients with high-risk endometrial cancer: A FRANCOGYN study - Archive ouverte HAL Access content directly
Journal Articles Journal of Gynecology Obstetrics and Human Reproduction Year : 2022

Impact of severe obesity in the management of patients with high-risk endometrial cancer: A FRANCOGYN study

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Cyril Touboul
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Yohan Dabi
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Yohan Kerbage
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Cherif Akladios
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Lise Lecointre
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Abstract

Objective: To assess the surgical management and survival of severely obese patients with high-risk endometrial cancer. Materials and methods: Data from 269 patients with high-risk endometrial cancer who were treated between 2001 and 2018 were collected from a multicenter database (11 centers). We classified the patients according to their BMI and compared outcomes in two groups: a normal weight group of women with a BMI < 25 kg/m2, and a severe obesity group of women with a BMI ≥ 35 kg/m2. The groups were compared for epidemiologic, pathologic, management, relapse-free survival (RFS) and overall survival (OS) elements. Results: Patients in the severe obesity group were younger (64 years vs. 68 years, p < 0.05) and had more comorbidities (hypertension, diabetes). They also had more locally advanced tumors and pelvic lymph node involvement (47% vs 24%, p < 0.05). The severely obese patients were less likely to undergo recommended surgical staging, with fewer lumbar aortic dissections than women of normal weight (23% vs 36%, p < 0.05) and fewer pelvic sentinel lymph node biopsies (26.5% vs 12.1%, p < 0.05). No difference in RFS or OS were observed between the two groups. Conclusion: Patients with severe obesity and high-risk endometrial cancer have more locally advanced tumors, and are less likely to be managed according to surgical recommendations. However, RFS and OS do not seem to be affected.
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hal-03789343 , version 1 (14-10-2022)

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Ombline Simon, Ludivine Dion, Krystel Nyangoh Timoh, Pierre François Dupré, Henri Azaïs, et al.. Impact of severe obesity in the management of patients with high-risk endometrial cancer: A FRANCOGYN study. Journal of Gynecology Obstetrics and Human Reproduction, 2022, 51 (7), pp.102429. ⟨10.1016/j.jogoh.2022.102429⟩. ⟨hal-03789343⟩
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