Challenges in glioblastoma research: focus on the tumor microenvironment - Archive ouverte HAL Access content directly
Journal Articles Trends in Cancer Year : 2022

Challenges in glioblastoma research: focus on the tumor microenvironment

(1) , (2) , (3, 4) , (5) , (6) , (1) , (7) , (8, 9) , (3, 4) , (10) , (11, 12) , (13) , (13) , (14) , (15) , (16, 17) , (15) , (18) , (19, 20) , (8, 9) , (16, 17) , (21, 22) , (7) , (23) , (6) , (24, 25) , (10) , (1) , (11, 12) , (26) , (27, 28) , (8, 9) , (3, 4) , (29, 30) , (5) , (19, 20) , (25, 24) , (31) , (32) , (32) , (33) , (7) , (21, 22) , (24, 25) , (33)
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
Tony Avril
  • Function : Author
  • PersonId : 1025422
Luc Bauchet
  • Function : Author
  • PersonId : 913075
Lucie Brisson
Hervé Chneiweiss
Monique Dontenwill
  • Function : Author
  • PersonId : 1079917
Jean-Philippe Hugnot
  • Function : Author
  • PersonId : 1067797
Marie-Pierre Junier
  • Function : Author
  • PersonId : 865364
Thomas Mathivet
Véronique Rousseau
  • Function : Author
  • PersonId : 867252
Giorgio Seano
Emeline Tabouret
Laurent Turchi
Thierry Virolle

Abstract

Glioblastoma (GBM) is the most deadly type of malignant brain tumor, despite extensive molecular analyses of GBM cells. In recent years, the tumor microenvironment (TME) has been recognized as an important player and therapeutic target in GBM. However, there is a need for a full and integrated understanding of the different cellular and molecular components involved in the GBM TME and their interactions for the development of more efficient therapies. In this review, we provide a comprehensive report of the GBM TME, which assembles the contributions of physicians and translational researchers working on brain tumor pathology and therapy in France. We propose a holistic view of the subject by delineating the specific features of the GBM TME at the cellular, molecular, and therapeutic levels.
Embargoed file
Embargoed file
0 9 28
Year Month Jours
Avant la publication

Dates and versions

hal-03860005 , version 1 (24-11-2022)

Licence

Attribution - NonCommercial - NoDerivatives - CC BY 4.0

Identifiers

Cite

Andreas Bikfalvi, Cristine Alves da Costa, Tony Avril, Jean-Vianney Barnier, Luc Bauchet, et al.. Challenges in glioblastoma research: focus on the tumor microenvironment. Trends in Cancer, 2022, 8033 (22), pp.00220-5. ⟨10.1016/j.trecan.2022.09.005⟩. ⟨hal-03860005⟩
0 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More