, After purification on silica gel CH2Cl2, 3d was obtained (115 mg, 89 %) as a brown solid, p.300
,
, Hz, 1 H), 7.10 (dd, J= 1.8 Hz, J= 8.8 Hz, 1 H), vol.7
, 7.67 (s, 1 H), 7.97 (d, J= 8.9 Hz, 1 H) , 8.51 (d, J= 7.7 Hz, p.1
, After purification on silica gel CH2Cl2, 3e was obtained (120 mg, 93 %) as a brown solid, 13 C NMR 75MHz, CDCl3): ?, p.300
,
, , p.1
, acridine (4a). After purification on silica gel (PE/CH2Cl2 : 90/10), 4a was obtained (160 mg, 58 %) as a brown solid. m.p. 160 °C. 1 H NMR (300 MHz, CDCl3): ? 3.13 (br., 4 H), vol.7
, Hz, 1 H), 9.98 (d, J= 8.7 Hz, 1 H). 13 C NMR (75 MHz, CDCl3): ? 28, vol.8
, After purification on silica gel (PE/CH2Cl2 : 90/10), 4b was obtained (110 mg, 80 %) as a brown solid. m.p. : 150 °C. 1 H NMR (300 MHz, CDCl3): ? 1.94-2.01 (m, 4 H)
, 3.07 (br., 4 H), 3.49-3.53 (m, 2 H), 7.24-7.27 (m, 1 H), 7.42 (d, J= 8.1 Hz, 1 H), 7.49-7.55 (m, 2 H), vol.7, p.1
, 13 C NMR (75 MHz, CDCl3): ? 23
, After purification on silica gel (PE/CH2Cl2 : 90/10), 4c was obtained (80 mg, 58 %) as a brown solid, p.1
, 13 C NMR (75 MHz, CDCl3): ? 23
, After purification on silica gel CH2Cl2, 4d was obtained (54 mg, 83%) as a brown solid, pp.152-153
, CDCl3): ? 3.03 (br., 4 H), 6.92 (d, J= 2.6 Hz, 1 H), 7.16 (dd, J= 2.6 Hz, J= 7.1 Hz, 1 H)
, After purification on silica gel CH2Cl2, Hz, 1 H). 13 C NMR (75 MHz, CDCl3): ? 29.2, 30.1, 106.9
, CDCl3): ? 3.13 (br., 4 H), vol.7, p.1
, 7.92 (t, J= 8 Hz, vol.16
, Hz, 1 H), 8.42 (d, J= 2.4 Hz, 1 H), 8.74 (d, J= 2.3 Hz, 1 H), 9.68 (d, J= 8.7 Hz, 1 H). 13 C NMR (75 MHz, CDCl3
, After purification on silica gel (PE/CH2Cl2 : 90/10), 4f was obtained (65 mg, 93%) as a yellow oil, vol.13
, Hz, 1 H), 6.93 (d, J= 9 Hz, 1 H), 7.40 (d, J= 6 Hz, 1 H), 7.51 (t, J= 6 Hz, J= 15 Hz, 1 H), 7.65 (t, J= 6 Hz, J= 15 Hz, 1 H), 7.85 (t, J= 6 Hz, J= 15 Hz, 1 H), (s, 1 H), 9.99 (d, J= 6 Hz, 1 H). 13 C NMR (75 MHz, CDCl3): ? 29
, After purification on silica gel (PE/ACOEt : 98/02), 4g was obtained (40 mg, 93%) as a yellow solid. m.p.: 190 °C 1 H NMR (300 MHz, CDCl3): ? 7.74-7.88 (m, 4 H)
,
, After purification on silica gel (PE/CH2Cl2 : 50/50), 5 was obtained (250 mg, 70%) as a yellow solid, vol.14, p.18
, Hz, 1 H). 13 C NMR (75 MHz, CDCl3): ? 28
, After purification on silica gel (PE/CH2Cl2 : 50/50), 6 was obtained (35 mg, 88%) as a white solid. m.p. 265 °C. 1 H NMR (300 MHz, CDCl3): ? 3.13-3.21 (m, 4 H), vol.7, p.1
, m, 2 H), 8.38 (s, 1 H), 8.77 (s, 1 H, vol.9
, HRMS-ESI: m/z [M + H] + calcd for C36H25N2: 485, vol.29, p.485, 2013.
, After purification on silica gel (PE/CH2Cl2 : 90/10), 7 was obtained (54 mg, 29%) as a yellow solid. m.p. : 92 °C. 1 H NMR (300 MHz, CDCl3): ? 3.04-3.11 (m, 4 H), 3.16-3.20 (m, 2 H), 3.29-3.33 (m, 2 H), 7.31 (d, J= 7.4 Hz, 1 H), 7.38-7.52 (m, 4 H), vol.7, p.300
HRMS-ESI: m/z [M + H] + calcd for C28H21N2: 385.1705; found: 385.1710. References and notes 1, Bioorg. Med. Chem. Lett, vol.128, issue.2, pp.1863-1872, 2007. ,
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