Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans, J. Immunol, vol.190, pp.6187-6197, 2013. ,
Bcl-2 and Bax mammalian regulators of apoptosis are functional in Drosophila, Cell Death Differ, vol.7, pp.804-814, 2000. ,
, A gain-of
, HPCs transduced as above with TMEM131L or the empty vector (pRRL) were cultured for two weeks under the T condition before FACS analysis. Gates are set on CD45 þ GFP þ transduced cells. Dashed arrows show the gating strategy. Bi-dimensional dot-plots show expression of CD34/ CD7, CD4/CD8, CD33/CD11b. (C) Bar plots show the percentages of CD34 À CD7 À monocytic and CD34 À CD7 þ T cell precursors. Data are from two independent experiments performed in duplicates, Effect of TMEM131L on T cell development. CD34 þ
, D) Effect of TMEM131L on B cell development. CD34 þ HPCs transduced with TMEM131L or the empty vector (pRRL) were cultured for two weeks under the B condition before being analyzed as above. Gates are set on CD45 þ GFP þ cells. Bi-dimensional dot-plots show expression of CD19/CD10. Data are from one experiment out of three. responses to the hedgehog gradient, Dev. Biol, vol.228, pp.211-224, 2000.
Drosophila Minus is required for cell proliferation and influences Cyclin E turnover, Genes Dev, vol.23, 2009. ,
, Dynamics of thymus-colonizing cells during human development, vol.24, pp.217-230, 2006.
URL : https://hal.archives-ouvertes.fr/inserm-00164311
AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway, Blood, vol.118, pp.1784-1796, 2011. ,
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes, Development, vol.118, pp.401-415, 1993. ,
Hedgehog signal transduction in the posterior compartment of the Drosophila wing imaginal disc, Mol. Cell, vol.6, pp.479-485, 2000. ,
Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc, Development, vol.122, pp.359-369, 1996. ,
Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing, Development, vol.121, pp.4215-4225, 1995. ,
Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila, Cell, vol.102, pp.349-362, 2000. ,
Fat and Wingless signaling oppositely regulate epithelial cell-cell adhesion and distal wing development in Drosophila, Development, vol.133, pp.925-935, 2006. ,
Visualization of gene expression in living adult Drosophila, Science, vol.274, pp.252-255, 1996. ,
Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi, Nature, vol.458, pp.987-992, 2009. ,
Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells, Blood, vol.114, pp.972-982, 2009. ,
GATA-3 promotes T-cell specification by repressing B-cell potential in pro-T cells in mice, Blood, vol.121, pp.1749-1759, 2013. ,