C. J. Sherr and F. Mccormick, The RB and p53 pathways in cancer, Cancer Cell, vol.2, issue.02, pp.102-104, 2002.

D. Cobrinik, Pocket proteins and cell cycle control, Oncogene, vol.24, pp.2796-809, 2005.

A. Almasan, Y. Yin, R. E. Kelly, E. Y. Lee, A. Bradley et al., Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis, Proc Natl Acad Sci U S A, vol.92, pp.5436-5476, 1995.

A. Ianari, T. Natale, E. Calo, E. Ferretti, E. Alesse et al., Proapoptotic function of the retinoblastoma tumor suppressor protein, Cancer Cell, vol.15, pp.184-94, 2009.


K. I. Hilgendorf, E. S. Leshchiner, S. Nedelcu, M. A. Maynard, E. Calo et al., The retinoblastoma protein induces apoptosis directly at the mitochondria, Genes Dev, vol.27, pp.1003-1018, 2013.


K. Y. Tsai, Y. Hu, K. F. Macleod, D. Crowley, L. Yamasaki et al., Mutation of E2F-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos, Mol Cell, vol.2, pp.80274-80283, 1998.

A. Sharma, C. E. Comstock, E. S. Knudsen, K. H. Cao, J. K. Hess-wilson et al., Retinoblastoma tumor suppressor status is a critical determinant of therapeutic response in prostate cancer cells, Cancer Res, vol.67, pp.6192-203, 2007.

M. S. Huh, M. H. Parker, A. Scime, R. Parks, and M. A. Rudnicki, Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation, J Cell Biol, vol.166, pp.865-76, 2004.


G. Palacios, F. Talos, A. Nemajerova, U. M. Moll, and O. Petrenko, E2F1 plays a direct role in Rb stabilization and p53-independent tumor suppression, Cell Cycle, vol.7, pp.1776-81, 2008.

C. Milet, A. Rincheval-arnold, B. Mignotte, and I. Guenal, The Drosophila retinoblastoma protein induces apoptosis in proliferating but not in post-mitotic cells, Cell Cycle, vol.9, pp.97-103, 2010.

C. Milet, A. Rincheval-arnold, A. Morieras, A. Clavier, A. Garrigue et al., Mutating RBF can enhance its pro-apoptotic activity and uncovers a new role in tissue homeostasis, PLoS One, vol.9, 2014.

T. Igaki, Correcting developmental errors by apoptosis: lessons from Drosophila JNK signaling, Apoptosis, vol.14, pp.1021-1029, 2009.


B. Biteau, J. Karpac, D. Hwangbo, and H. Jasper, Regulation of Drosophila lifespan by JNK signaling, Exp Gerontol, vol.46, pp.349-54, 2011.


D. N. Dhanasekaran and E. P. Reddy, JNK signaling in apoptosis, Oncogene, vol.27, pp.6245-51, 2008.

A. Clavier, A. Baillet, A. Rincheval-arnold, A. Coleno-costes, C. Lasbleiz et al., The pro-apoptotic activity of Drosophila Rbf1 involves dE2F2-dependent downregulation of diap1 and buffy mRNA, Cell Death Dis, vol.5, 1405.
URL : https://hal.archives-ouvertes.fr/hal-01311569

E. Martin-blanco, A. Gampel, J. Ring, K. Virdee, N. Kirov et al., Martinez-Arias A. puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila, Genes Dev, vol.12, pp.557-70, 1998.

Y. Demay, J. Perochon, S. Szuplewski, B. Mignotte, and S. Gaumer, The PERK pathway independently triggers apoptosis and a Rac1/Slpr/ JNK/Dilp8 signaling favoring tissue homeostasis in a chronic ER stress Drosophila model, Cell Death Dis, vol.5, 1452.


C. Marchal, G. Vinatier, M. Sanial, A. Plessis, A. M. Pret et al., The HIV-1 Vpu protein induces apoptosis in Drosophila via activation of JNK signaling, PLoS One, vol.7, p.34310, 2012.



H. D. Ryoo, T. Gorenc, and H. Steller, Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways, Dev Cell, vol.7, pp.491-501, 2004.

C. Bergantinos, M. Corominas, and F. Serras, Cell death-induced regeneration in wing imaginal discs requires JNK signalling, Development, vol.137, pp.1169-79, 2010.

Y. Fan, S. Wang, J. Hernandez, V. B. Yenigun, G. Hertlein et al., Genetic models of apoptosis-induced proliferation decipher activation of JNK and identify a requirement of EGFR signaling for tissue regenerative responses in Drosophila, PLoS Genet, vol.10, 2014.

S. C. Herrera, R. Martin, and G. Morata, Tissue homeostasis in the wing disc of Drosophila melanogaster: immediate response to massive damage during development, PLoS Genet, vol.9, 2013.


B. Stronach, A. L. Lennox, and R. A. Garlena, Domain specificity of MAP3K family members, MLK and Tak1, for JNK signaling in Drosophila, Genetics, vol.197, pp.497-513, 2014.

P. Geuking, R. Narasimamurthy, and K. Basler, A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of Drosophila TAB2 as a functionally conserved component, Genetics, vol.171, pp.1683-94, 2005.

D. S. Andersen, J. Colombani, V. Palmerini, K. Chakrabandhu, E. Boone et al., The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth, Nature, vol.522, issue.7557, pp.482-488, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01255294

E. Kuranaga, H. Kanuka, T. Igaki, K. Sawamoto, H. Ichijo et al., Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila, Nat Cell Biol, vol.4, pp.705-715, 2002.

H. Kanda and M. Miura, Regulatory roles of JNK in programmed cell death, J Biochem, vol.136, pp.1-6, 2004.

A. Clavier, V. Ruby, A. Rincheval-arnold, B. Mignotte, and I. Guenal, The Drosophila retinoblastoma protein, Rbf1, induces a Debcl-and Drp1-dependent mitochondrial apoptosis, J Cell Sci, vol.128, pp.3239-3288, 2015.


Y. Son, S. Kim, H. T. Chung, and P. Ho, Reactive oxygen species in the activation of MAP kinases, Methods Enzymol, vol.528, pp.27-48, 2013.


H. Nakano, A. Nakajima, S. Sakon-komazawa, J. H. Piao, X. Xue et al., Reactive oxygen species mediate crosstalk between NF-kap-paB and JNK, Cell Death Differ, vol.13, pp.730-737, 2006.


S. Zhou, D. Yu, S. Ning, H. Zhang, L. Jiang et al., Augmented Rac1 Expression and Activity are Associated with Oxidative Stress and Decline of b Cell Function in Obesity, Cell Physiol Biochem, vol.35, pp.2135-2183, 2015.

G. Sun and K. D. Irvine, Ajuba family proteins link JNK to Hippo signaling, Sci Signal, vol.6, p.81, 2013.

M. Wu, J. C. Pastor-pareja, and T. Xu, Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion, Nature, vol.463, pp.545-553, 2010.

R. Simon, R. Aparicio, B. E. Housden, S. Bray, and A. Busturia, Drosophila p53 controls Notch expression and balances apoptosis and proliferation, Apoptosis, vol.19, pp.1430-1473, 2014.

S. Brun, V. Rincheval, S. Gaumer, B. Mignotte, and I. Guenal, reaper and bax initiate two different apoptotic pathways affecting mitochondria and antagonized by bcl-2 in Drosophila, Oncogene, vol.21, pp.6458-70, 2002.