E. Abdelwahid, T. Yokokura, R. J. Krieser, S. Balasundaram, W. H. Fowle et al., Mitochondrial disruption in Drosophila apoptosis, Dev. Cell, vol.12, pp.793-806, 2007.

N. Allaman-pillet, A. Oberson, and D. F. Schorderet, BIRO1, a cell permeable BH3 peptide, promotes mitochondrial fragmentation and death of retinoblastoma cells, Mol. Cancer Res, vol.13, pp.86-97, 2015.

A. M. Ambrus, A. B. Islam, K. B. Holmes, N. S. Moon, N. Lopez-bigas et al., Loss of dE2F compromises mitochondrial function, Dev. Cell, vol.27, pp.438-451, 2013.

D. Arnoult, N. Rismanchi, A. Grodet, R. G. Roberts, D. P. Seeburg et al., Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death, Curr. Biol, vol.15, pp.2112-2118, 2005.

M. Bergeaud, L. Mathieu, A. Guillaume, U. Moll, B. Mignotte et al., Mitochondrial p53 mediates a transcription-independent regulation of cell respiration and interacts with the mitochondrial F1F0-ATP synthase, Cell Cycle, vol.12, pp.2781-2793, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01871462

J. Bertin-ciftci, B. Barre, J. Le-pen, L. Maillet, C. Couriaud et al., pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737, Cell Death Differ, vol.20, pp.755-764, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-02447042

D. Biasoli, S. A. Kahn, T. A. Corne?io, M. Furtado, L. Campanati et al., Retinoblastoma protein regulates the crosstalk between autophagy and apoptosis, and favors glioblastoma resistance to etoposide, Cell Death Dis, vol.4, p.767, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01541435

M. L. Boland, A. H. Chourasia, and K. F. Macleod, Mitochondrial dysfunction in cancer, Front. Oncol, vol.3, p.292, 2013.

C. Bowen, S. Spiegel, and E. P. Gelmann, Radiation-induced apoptosis mediated by retinoblastoma protein, Cancer Res, vol.58, pp.3275-3281, 1998.

C. B. Brachmann, O. W. Jassim, B. D. Wachsmuth, and R. L. Cagan, , 2000.

, The Drosophila bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation, Curr. Biol, vol.10, pp.547-550

A. P. Bracken, M. Ciro, A. Cocito, and K. Helin, E2F target genes: unraveling the biology, Trends Biochem. Sci, vol.29, pp.409-417, 2004.

D. G. Breckenridge, M. Stojanovic, R. C. Marcellus, and G. C. Shore, , 2003.

, Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol, J. Cell Biol, vol.160, pp.1115-1127

C. Brooks, Q. Wei, L. Feng, G. Dong, Y. Tao et al., Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins, Proc. Natl. Acad. Sci. USA, vol.104, pp.11649-11654, 2007.

S. Brun, V. Rincheval, S. Gaumer, B. Mignotte, and I. Guenal, reaper and bax initiate two different apoptotic pathways affecting mitochondria and antagonized by bcl-2 in Drosophila, Oncogene, vol.21, pp.6458-6470, 2002.

M. Challa, S. Malladi, B. J. Pellock, D. Dresnek, S. Varadarajan et al., Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease, EMBO J, vol.26, pp.3144-3156, 2007.

C. Claveria, E. Caminero, C. Martinez-a, S. Campuzano, and M. Torres, GH3, a novel proapoptotic domain in Drosophila Grim, promotes a mitochondrial death pathway, EMBO J, vol.21, pp.3327-3336, 2002.

A. Clavier, A. Baillet, A. Rincheval-arnold, A. Cole?o-costes, C. Lasbleiz et al., The pro-apoptotic activity of Drosophila Rbf1 involves dE2F2-dependent downregulation of diap1 and buffy mRNA, Cell Death Dis, vol.5, p.1405, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01311569

J. Colin, J. Garibal, A. Clavier, A. Rincheval-arnold, S. Gaumer et al., The Drosophila Bcl-2 family protein Debcl is targeted to the proteasome by the beta-TrCP homologue slimb, Apoptosis, vol.19, pp.1444-1456, 2014.

P. A. Colussi, L. M. Quinn, D. C. Huang, M. Coombe, S. H. Read et al., Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery, J. Cell Biol, vol.148, pp.703-714, 2000.

S. Desagher and J. Martinou, Mitochondria as the central control point of apoptosis, Trends Cell Biol, vol.10, pp.369-377, 2000.

D. Fiore, R. D'anneo, A. Tesoriere, G. Vento, and R. , RB1 in cancer: different mechanisms of RB1 inactivation and alterations of pRb pathway in tumorigenesis, J. Cell Physiol, vol.228, pp.1676-1687, 2013.

L. Dorstyn, S. Read, D. Cakouros, J. R. Huh, B. A. Hay et al., The role of cytochrome c in caspase activation in Drosophila melanogaster cells, J. Cell Biol, vol.156, pp.1089-1098, 2002.

L. Dorstyn, K. Mills, Y. Lazebnik, and S. Kumar, The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells, J. Cell Biol, vol.167, pp.405-410, 2004.

J. Estaquier, F. Vallette, J. Vayssiere, and B. Mignotte, The mitochondrial pathways of apoptosis, Adv. Exp. Med. Biol, vol.942, pp.157-183, 2012.

S. Frank, B. Gaume, E. S. Bergmann-leitner, W. W. Leitner, E. G. Robert et al., The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis, Dev. Cell, vol.1, pp.515-525, 2001.
URL : https://hal.archives-ouvertes.fr/hal-00153696

C. D. Freel, D. A. Richardson, M. J. Thomenius, E. C. Gan, S. R. Horn et al., Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions, J. Biol. Chem, vol.283, pp.367-379, 2008.

K. A. Galindo, W. Lu, J. H. Park, and J. M. Abrams, The Bax/Bak ortholog in Drosophila, Debcl, exerts limited control over programmed cell death, Development, vol.136, pp.275-283, 2009.

A. J. Garcia-saéz, The secrets of the Bcl-2 family, Cell Death Differ, vol.19, pp.1733-1740, 2012.

G. Goyal, B. Fell, A. Sarin, R. J. Youle, and V. Sriram, Role of mitochondrial remodeling in programmed cell death in Drosophila melanogaster, Dev. Cell, vol.12, pp.807-816, 2007.

D. R. Green, L. Galluzzi, and G. Kroemer, Metabolic control of cell death, Science, vol.345, p.1250256, 2014.

H. Hao, Y. Dong, M. T. Bowling, J. G. Gomez-gutierrez, H. S. Zhou et al., E2F-1 induces melanoma cell apoptosis via PUMA upregulation and Bax translocation, BMC Cancer, vol.7, p.24, 2007.

J. M. Hardwick and L. Soane, Multiple functions of BCL-2 family proteins, Cold Spring Harb. Perspect. Biol, vol.5, p.8722, 2013.

T. Hershko and D. Ginsberg, Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis, J. Biol. Chem, vol.279, pp.8627-8634, 2004.

K. I. Hilgendorf, E. S. Leshchiner, S. Nedelcu, M. A. Maynard, E. Calo et al., The retinoblastoma protein induces apoptosis directly at the mitochondria, Genes Dev, vol.27, pp.1003-1015, 2013.

A. Ianari, T. Natale, E. Calo, E. Ferretti, E. Alesse et al., Proapoptotic function of the retinoblastoma tumor suppressor protein, Cancer Cell, vol.15, pp.184-194, 2009.

T. Igaki, H. Kanuka, N. Inohara, K. Sawamoto, G. Nunez et al., Drob-1, a Drosophila member of the bcl-2/CED-9 family that promotes cell death, Proc. Natl. Acad. Sci. USA, vol.97, pp.662-667, 2000.

M. Karbowski, Y. Lee, B. Gaume, S. Jeong, S. Frank et al., Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis, J. Cell Biol, vol.159, pp.931-938, 2002.

M. Karbowski, D. Arnoult, H. Chen, D. C. Chan, C. L. Smith et al., Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis, J. Cell Biol, vol.164, pp.493-499, 2004.

R. Lin, A. Angelin, F. Da-settimo, C. Martini, S. Taliani et al., Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and A?42-induced neurodegeneration, Aging Cell, vol.13, pp.507-518, 2014.

J. C. Means, I. Muro, and R. J. Clem, Lack of involvement of mitochondrial factors in caspase activation in a Drosophila cell-free system, Cell Death Differ, vol.13, pp.1222-1234, 2006.

C. S. Mendes, E. Arama, S. Brown, H. Scherr, M. Srivastava et al., Cytochrome c-d regulates developmental apoptosis in the Drosophila retina, EMBO Rep, vol.7, pp.933-939, 2006.

C. Milet, A. Rincheval-arnold, B. Mignotte, and I. Gue?al, The Drosophila retinoblastoma protein induces apoptosis in proliferating but not in post-mitotic cells, Cell Cycle, vol.9, pp.97-103, 2010.

C. Milet, A. Rincheval-arnold, A. Morie?as, A. Clavier, A. Garrigue et al., Mutating RBF can enhance its pro-apoptotic activity and uncovers a new role in tissue homeostasis, PLoS ONE, vol.9, p.102902, 2014.

A. Morales, A. Alvarez, F. Arvelo, A. I. Sua?ez, R. S. Compagnone et al., The natural diterpene ent-16beta-17alpha-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2alpha/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells, Apoptosis, vol.16, pp.1245-1252, 2011.

S. D. Morgenbesser, B. O. Williams, T. Jacks, and R. A. Depinho, p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens, Nature, vol.371, pp.72-74, 1994.

J. Morishita, M. Kang, K. Fidelin, and H. D. Ryoo, CDK7 regulates the mitochondrial localization of a tail-anchored proapoptotic protein, Hid. Cell Rep, vol.5, pp.1481-1488, 2013.

M. Neuspiel, R. Zunino, S. Gangaraju, P. Rippstein, and H. Mcbride, Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization, J. Biol. Chem, vol.280, pp.25060-25070, 2005.

M. R. Olson, C. L. Holley, E. C. Gan, D. A. Colon-ramos, B. Kaplan et al., A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation, J. Biol. Chem, vol.278, pp.44758-44768, 2003.

J. Park, H. Choi, J. Min, S. Park, J. Kim et al., Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells, J. Neurochem, vol.127, pp.221-232, 2013.

X. Qi, N. Qvit, Y. Su, and D. Mochly-rosen, A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity, J. Cell Sci, vol.126, pp.789-802, 2013.

L. Quinn, M. Coombe, K. Mills, T. Daish, P. Colussi et al., Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions, EMBO J, vol.22, pp.3568-3579, 2003.

S. G. Rolland and B. Conradt, New role of the BCL2 family of proteins in the regulation of mitochondrial dynamics, Curr. Opin. Cell Biol, vol.22, pp.852-858, 2010.

C. Sandu, H. D. Ryoo, and H. Steller, Drosophila IAP antagonists form multimeric complexes to promote cell death, J. Cell Biol, vol.190, pp.1039-1052, 2010.

N. Senoo-matsuda, T. Igaki, and M. Miura, Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila, EMBO J, vol.24, pp.2700-2713, 2005.

E. A. Sevrioukov, J. Burr, E. W. Huang, H. H. Assi, J. P. Monserrate et al., Drosophila Bcl-2 proteins participate in stress-induced apoptosis, but are not required for normal development, Genesis, vol.45, pp.184-193, 2007.

C. Sheridan, P. Delivani, S. P. Cullen, and S. J. Martin, Bax-or Bakinduced mitochondrial fission can be uncoupled from cytochrome C release, Mol. Cell, vol.31, pp.570-585, 2008.

Y. Son, S. Kim, H. Chung, and H. Pae, Reactive oxygen species in the activation of MAP kinases, Methods Enzymol, vol.528, pp.27-48, 2013.

S. W. Tait and D. R. Green, Mitochondrial regulation of cell death, Cold Spring Harb. Perspect. Biol, vol.5, p.8706, 2013.

M. Thomenius, C. D. Freel, S. Horn, R. Krieser, E. Abdelwahid et al., Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death, Cell Death Differ, vol.18, pp.1640-1650, 2011.

K. Y. Tsai, Y. Hu, K. F. Macleod, D. Crowley, L. Yamasaki et al., Mutation of E2F-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos, Mol. Cell, vol.2, pp.293-304, 1998.

A. Tsubouchi, T. Tsuyama, M. Fujioka, H. Kohda, K. Okamoto-furuta et al., Mitochondrial protein Preli-like is required for development of dendritic arbors and prevents their regression in the Drosophila sensory nervous system, Development, vol.136, pp.3757-3766, 2009.

J. Varkey, P. Chen, R. Jemmerson, and J. M. Abrams, Altered cytochrome c display precedes apoptotic cell death in Drosophila, J. Cell Biol, vol.144, pp.701-710, 1999.

P. Verstreken, C. V. Ly, K. J. Venken, T. Koh, Y. Zhou et al., Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions, Neuron, vol.47, pp.365-378, 2005.

S. Wasiak, R. Zunino, and H. M. Mcbride, Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death, J. Cell Biol, vol.177, pp.439-450, 2007.

H. Zhang, Q. Huang, N. Ke, S. Matsuyama, B. Hammock et al., Drosophila pro-apoptotic Bcl-2/Bax homologue reveals evolutionary conservation of cell death mechanisms, J. Biol. Chem, vol.275, pp.27303-27306, 2000.

Y. Zhao, J. Tan, L. Zhuang, X. Jiang, E. T. Liu et al., Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim, Proc. Natl. Acad. Sci. USA, vol.102, pp.16090-16095, 2005.

K. C. Zimmermann, J. Ricci, N. M. Droin, and D. R. Green, The role of ARK in stress-induced apoptosis in Drosophila cells, J. Cell Biol, vol.156, pp.1077-1087, 2002.