Mitochondrial disruption in Drosophila apoptosis, Dev. Cell, vol.12, pp.793-806, 2007. ,
BIRO1, a cell permeable BH3 peptide, promotes mitochondrial fragmentation and death of retinoblastoma cells, Mol. Cancer Res, vol.13, pp.86-97, 2015. ,
Loss of dE2F compromises mitochondrial function, Dev. Cell, vol.27, pp.438-451, 2013. ,
Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death, Curr. Biol, vol.15, pp.2112-2118, 2005. ,
Mitochondrial p53 mediates a transcription-independent regulation of cell respiration and interacts with the mitochondrial F1F0-ATP synthase, Cell Cycle, vol.12, pp.2781-2793, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-01871462
pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737, Cell Death Differ, vol.20, pp.755-764, 2013. ,
URL : https://hal.archives-ouvertes.fr/inserm-02447042
Retinoblastoma protein regulates the crosstalk between autophagy and apoptosis, and favors glioblastoma resistance to etoposide, Cell Death Dis, vol.4, p.767, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-01541435
Mitochondrial dysfunction in cancer, Front. Oncol, vol.3, p.292, 2013. ,
Radiation-induced apoptosis mediated by retinoblastoma protein, Cancer Res, vol.58, pp.3275-3281, 1998. ,
, , 2000.
, The Drosophila bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation, Curr. Biol, vol.10, pp.547-550
E2F target genes: unraveling the biology, Trends Biochem. Sci, vol.29, pp.409-417, 2004. ,
, , 2003.
, Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol, J. Cell Biol, vol.160, pp.1115-1127
Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins, Proc. Natl. Acad. Sci. USA, vol.104, pp.11649-11654, 2007. ,
reaper and bax initiate two different apoptotic pathways affecting mitochondria and antagonized by bcl-2 in Drosophila, Oncogene, vol.21, pp.6458-6470, 2002. ,
Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease, EMBO J, vol.26, pp.3144-3156, 2007. ,
GH3, a novel proapoptotic domain in Drosophila Grim, promotes a mitochondrial death pathway, EMBO J, vol.21, pp.3327-3336, 2002. ,
The pro-apoptotic activity of Drosophila Rbf1 involves dE2F2-dependent downregulation of diap1 and buffy mRNA, Cell Death Dis, vol.5, p.1405, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01311569
The Drosophila Bcl-2 family protein Debcl is targeted to the proteasome by the beta-TrCP homologue slimb, Apoptosis, vol.19, pp.1444-1456, 2014. ,
Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery, J. Cell Biol, vol.148, pp.703-714, 2000. ,
Mitochondria as the central control point of apoptosis, Trends Cell Biol, vol.10, pp.369-377, 2000. ,
RB1 in cancer: different mechanisms of RB1 inactivation and alterations of pRb pathway in tumorigenesis, J. Cell Physiol, vol.228, pp.1676-1687, 2013. ,
The role of cytochrome c in caspase activation in Drosophila melanogaster cells, J. Cell Biol, vol.156, pp.1089-1098, 2002. ,
The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells, J. Cell Biol, vol.167, pp.405-410, 2004. ,
The mitochondrial pathways of apoptosis, Adv. Exp. Med. Biol, vol.942, pp.157-183, 2012. ,
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis, Dev. Cell, vol.1, pp.515-525, 2001. ,
URL : https://hal.archives-ouvertes.fr/hal-00153696
Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions, J. Biol. Chem, vol.283, pp.367-379, 2008. ,
The Bax/Bak ortholog in Drosophila, Debcl, exerts limited control over programmed cell death, Development, vol.136, pp.275-283, 2009. ,
The secrets of the Bcl-2 family, Cell Death Differ, vol.19, pp.1733-1740, 2012. ,
Role of mitochondrial remodeling in programmed cell death in Drosophila melanogaster, Dev. Cell, vol.12, pp.807-816, 2007. ,
Metabolic control of cell death, Science, vol.345, p.1250256, 2014. ,
E2F-1 induces melanoma cell apoptosis via PUMA upregulation and Bax translocation, BMC Cancer, vol.7, p.24, 2007. ,
Multiple functions of BCL-2 family proteins, Cold Spring Harb. Perspect. Biol, vol.5, p.8722, 2013. ,
Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis, J. Biol. Chem, vol.279, pp.8627-8634, 2004. ,
The retinoblastoma protein induces apoptosis directly at the mitochondria, Genes Dev, vol.27, pp.1003-1015, 2013. ,
Proapoptotic function of the retinoblastoma tumor suppressor protein, Cancer Cell, vol.15, pp.184-194, 2009. ,
Drob-1, a Drosophila member of the bcl-2/CED-9 family that promotes cell death, Proc. Natl. Acad. Sci. USA, vol.97, pp.662-667, 2000. ,
Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis, J. Cell Biol, vol.159, pp.931-938, 2002. ,
Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis, J. Cell Biol, vol.164, pp.493-499, 2004. ,
Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and A?42-induced neurodegeneration, Aging Cell, vol.13, pp.507-518, 2014. ,
Lack of involvement of mitochondrial factors in caspase activation in a Drosophila cell-free system, Cell Death Differ, vol.13, pp.1222-1234, 2006. ,
Cytochrome c-d regulates developmental apoptosis in the Drosophila retina, EMBO Rep, vol.7, pp.933-939, 2006. ,
The Drosophila retinoblastoma protein induces apoptosis in proliferating but not in post-mitotic cells, Cell Cycle, vol.9, pp.97-103, 2010. ,
Mutating RBF can enhance its pro-apoptotic activity and uncovers a new role in tissue homeostasis, PLoS ONE, vol.9, p.102902, 2014. ,
The natural diterpene ent-16beta-17alpha-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2alpha/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells, Apoptosis, vol.16, pp.1245-1252, 2011. ,
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens, Nature, vol.371, pp.72-74, 1994. ,
CDK7 regulates the mitochondrial localization of a tail-anchored proapoptotic protein, Hid. Cell Rep, vol.5, pp.1481-1488, 2013. ,
Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization, J. Biol. Chem, vol.280, pp.25060-25070, 2005. ,
A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation, J. Biol. Chem, vol.278, pp.44758-44768, 2003. ,
Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells, J. Neurochem, vol.127, pp.221-232, 2013. ,
A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity, J. Cell Sci, vol.126, pp.789-802, 2013. ,
Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions, EMBO J, vol.22, pp.3568-3579, 2003. ,
New role of the BCL2 family of proteins in the regulation of mitochondrial dynamics, Curr. Opin. Cell Biol, vol.22, pp.852-858, 2010. ,
Drosophila IAP antagonists form multimeric complexes to promote cell death, J. Cell Biol, vol.190, pp.1039-1052, 2010. ,
Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila, EMBO J, vol.24, pp.2700-2713, 2005. ,
Drosophila Bcl-2 proteins participate in stress-induced apoptosis, but are not required for normal development, Genesis, vol.45, pp.184-193, 2007. ,
Bax-or Bakinduced mitochondrial fission can be uncoupled from cytochrome C release, Mol. Cell, vol.31, pp.570-585, 2008. ,
Reactive oxygen species in the activation of MAP kinases, Methods Enzymol, vol.528, pp.27-48, 2013. ,
Mitochondrial regulation of cell death, Cold Spring Harb. Perspect. Biol, vol.5, p.8706, 2013. ,
Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death, Cell Death Differ, vol.18, pp.1640-1650, 2011. ,
Mutation of E2F-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos, Mol. Cell, vol.2, pp.293-304, 1998. ,
Mitochondrial protein Preli-like is required for development of dendritic arbors and prevents their regression in the Drosophila sensory nervous system, Development, vol.136, pp.3757-3766, 2009. ,
Altered cytochrome c display precedes apoptotic cell death in Drosophila, J. Cell Biol, vol.144, pp.701-710, 1999. ,
Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions, Neuron, vol.47, pp.365-378, 2005. ,
Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death, J. Cell Biol, vol.177, pp.439-450, 2007. ,
Drosophila pro-apoptotic Bcl-2/Bax homologue reveals evolutionary conservation of cell death mechanisms, J. Biol. Chem, vol.275, pp.27303-27306, 2000. ,
Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim, Proc. Natl. Acad. Sci. USA, vol.102, pp.16090-16095, 2005. ,
The role of ARK in stress-induced apoptosis in Drosophila cells, J. Cell Biol, vol.156, pp.1077-1087, 2002. ,