W. H. Lee, R. Bookstein, F. Hong, L. J. Young, and J. Y. Shew, Human retinoblastoma susceptibility gene: cloning, identification, and sequence, Science, vol.235, pp.1394-1399, 1987.

M. Classon and E. Harlow, The retinoblastoma tumour suppressor in development and cancer, Nat Rev Cancer, vol.2, pp.910-917, 2002.

E. J. Morris and N. J. Dyson, Retinoblastoma protein partners, Adv Cancer Res, vol.82, pp.1-54, 2001.

W. Du and J. Pogoriler, Retinoblastoma family genes, Oncogene, vol.25, pp.5190-5200, 2006.

D. Cobrinik, Pocket proteins and cell cycle control. Oncogene, vol.24, pp.2796-2809, 2005.

G. Bosco, Cell cycle: Retinoblastoma, a trip organizer, Nature, vol.466, pp.1051-1052, 2010.

D. L. Burkhart and J. Sage, Cellular mechanisms of tumour suppression by the retinoblastoma gene, Nat Rev Cancer, vol.8, pp.671-682, 2008.

P. Acharya, N. Negre, J. Johnston, Y. Wei, and K. P. White, Evidence for autoregulation and cell signaling pathway regulation from genome-wide binding of the Drosophila retinoblastoma protein, G3, vol.2, pp.1459-1472, 2012.

K. Y. Tsai, Y. Hu, K. F. Macleod, D. Crowley, and L. Yamasaki, Mutation of E2F-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos, Mol Cell, vol.2, pp.293-304, 1998.

S. D. Morgenbesser, B. O. Williams, T. Jacks, and R. A. Depinho, -dependent apoptosis produced by Rb-deficiency in the developing mouse lens, Nature, vol.371, pp.72-74, 1994.

J. K. Hsieh, F. S. Chan, D. J. O'connor, S. Mittnacht, and S. Zhong, RB regulates the stability and the apoptotic function of p53 via MDM2, Mol Cell, vol.3, pp.181-193, 1999.

A. Ianari, T. Natale, E. Calo, E. Ferretti, and E. Alesse, Proapoptotic function of the retinoblastoma tumor suppressor protein, Cancer Cell, vol.15, pp.184-194, 2009.

C. Lemaire, N. Godefroy, I. Costina-parvu, V. Rincheval, and F. Renaud, Caspase-9 can antagonize p53-induced apoptosis by generating a p76(Rb) truncated form of Rb, Oncogene, vol.24, pp.3297-3308, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00101331

E. O. Berge, S. Knappskog, S. Geisler, V. Staalesen, and M. Pacal, Identification and characterization of retinoblastoma gene mutations disturbing apoptosis in human breast cancers, Mol Cancer, vol.9, p.173, 2010.

A. Sharma, C. E. Comstock, E. S. Knudsen, K. H. Cao, and J. K. Hess-wilson, Retinoblastoma tumor suppressor status is a critical determinant of therapeutic response in prostate cancer cells, Cancer research, vol.67, pp.6192-6203, 2007.

C. Bowen, S. Spiegel, and E. P. Gelmann, Radiation-induced apoptosis mediated by retinoblastoma protein, Cancer Res, vol.58, pp.3275-3281, 1998.

K. E. Knudsen, E. Weber, K. C. Arden, W. K. Cavenee, and J. R. Feramisco, The retinoblastoma tumor suppressor inhibits cellular proliferation through two distinct mechanisms: inhibition of cell cycle progression and induction of cell death, Oncogene, vol.18, pp.5239-5245, 1999.

I. Ferecatu, L. Floch, N. Bergeaud, M. Rodriguez-enfedaque, A. Rincheval et al., Evidence for a mitochondrial localization of the retinoblastoma protein, BMC cell biology, vol.10, p.50, 2009.

K. I. Hilgendorf, E. S. Leshchiner, S. Nedelcu, M. A. Maynard, and E. Calo, The retinoblastoma protein induces apoptosis directly at the mitochondria, Genes & development, vol.27, pp.1003-1015, 2013.

R. U. Janicke, P. A. Walker, X. Y. Lin, and A. G. Porter, Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis, Embo J, vol.15, pp.6969-6978, 1996.

C. L. Fattman, B. An, and Q. P. Dou, Characterization of interior cleavage of retinoblastoma protein in apoptosis, J Cell Biochem, vol.67, pp.399-408, 1997.

W. D. Chen, J. Geradts, M. M. Keane, S. Lipkowitz, and M. Zajac-kaye, The 100-kDa proteolytic fragment of RB is retained predominantly within the nuclear compartment of apoptotic cells, Mol Cell Biol Res Commun, vol.1, pp.216-220, 1999.

A. L. Boutillier, E. Trinh, and J. P. Loeffler, Caspase-dependent cleavage of the retinoblastoma protein is an early step in neuronal apoptosis, Oncogene, vol.19, pp.2171-2178, 2000.

J. Bertin-ciftci, B. Barre, L. Pen, J. Maillet, L. Couriaud et al., pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737, Cell death and differentiation, vol.20, pp.755-764, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-02447042

X. Tan, S. J. Martin, and J. Wang, Degradation of Retinoblastoma protein in Tumor Necrosis Factor-and CD95-induced Cell Death, J Biol Chem, vol.272, pp.9613-9616, 1997.

C. L. Fattman, B. An, L. Sussman, and Q. P. Dou, -independent dephosphorylation and cleavage of retinoblastoma protein during tamoxifen-induced apoptosis in human breast carcinoma cells, Cancer Lett, vol.130, pp.103-113, 1998.

H. L. Borges, J. Bird, K. Wasson, R. D. Cardiff, and N. Varki, Tumor promotion by caspase-resistant retinoblastoma protein, Proc Natl Acad Sci U S A, vol.102, pp.15587-15592, 2005.

L. Floch, N. Rincheval, V. Ferecatu, I. Ali-boina, R. Renaud et al., The p76(Rb) and p100(Rb) truncated forms of the Rb protein exert antagonistic roles on cell death regulation in human cell lines, Biochemical and biophysical research communications, vol.399, pp.173-178, 2010.

A. P. Young and G. D. Longmore, Differential regulation of apoptotic genes by Rb in human versus mouse cells, Oncogene, vol.23, pp.2587-2599, 2004.

S. Van-den-heuvel and N. J. Dyson, Conserved functions of the pRB and E2F families, Nat Rev Mol Cell Biol, vol.9, pp.713-724, 2008.

H. Z. Chen, S. Y. Tsai, and G. Leone, Emerging roles of E2Fs in cancer: an exit from cell cycle control, Nat Rev Cancer, vol.9, pp.785-797, 2009.

M. V. Frolov and N. J. Dyson, Molecular mechanisms of E2F-dependent activation and pRB-mediated repression, J Cell Sci, vol.117, pp.2173-2181, 2004.

D. K. Dimova, O. Stevaux, M. V. Frolov, and N. J. Dyson, Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway, Genes Dev, vol.17, pp.2308-2320, 2003.

N. S. Moon, D. Stefano, L. Dyson, and N. , A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis, Mol Cell Biol, vol.26, pp.7601-7615, 2006.

N. S. Moon, D. Stefano, L. Morris, E. J. Patel, R. White et al., E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage, PLoS Genet, vol.4, p.1000153, 2008.

M. Tanaka-matakatsu, J. Xu, L. Cheng, and W. Du, Regulation of apoptosis of rbf mutant cells during Drosophila development, Dev Biol, vol.326, pp.347-356, 2009.

W. Du and N. Dyson, The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis, Embo J, vol.18, pp.916-925, 1999.

C. Milet, A. Rincheval-arnold, B. Mignotte, and I. Guenal, The Drosophila retinoblastoma protein induces apoptosis in proliferating but not in post-mitotic cells, Cell Cycle, vol.9, pp.97-103, 2010.

L. J. Wee, T. W. Tan, and S. Ranganathan, CASVM: web server for SVM-based prediction of caspase substrates cleavage sites, Bioinformatics, vol.23, pp.3241-3243, 2007.

L. J. Wee, T. W. Tan, and S. Ranganathan, SVM-based prediction of caspase substrate cleavage sites, BMC Bioinformatics, vol.7, 2006.

C. J. Hawkins, S. J. Yoo, E. P. Peterson, S. L. Wang, and S. Y. Vernooy, The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM, J Biol Chem, vol.275, pp.27084-27093, 2000.

S. J. Snipas, M. Drag, H. R. Stennicke, and G. S. Salvesen, Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC, Cell death and differentiation, vol.15, pp.938-945, 2008.

A. Perez-garijo, E. Shlevkov, and G. Morata, The role of Dpp and Wg in compensatory proliferation and in the formation of hyperplastic overgrowths caused by apoptotic cells in the Drosophila wing disc, Development, vol.136, pp.1169-1177, 2009.

M. I. Worley, L. Setiawan, and I. K. Hariharan, Regeneration and transdetermination in Drosophila imaginal discs, Annual review of genetics, vol.46, pp.289-310, 2012.

H. D. Ryoo and A. Bergmann, The role of apoptosis-induced proliferation for regeneration and cancer, Cold Spring Harbor perspectives in biology, vol.4, p.8797, 2012.

T. Igaki, Correcting developmental errors by apoptosis: lessons from Drosophila JNK signaling, Apoptosis, vol.14, pp.1021-1028, 2009.

H. D. Ryoo, T. Gorenc, and H. Steller, Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways, Dev Cell, vol.7, pp.491-501, 2004.

M. Hassler, S. Singh, W. W. Yue, M. Luczynski, and R. Lakbir, Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture, Molecular cell, vol.28, pp.371-385, 2007.

A. Perez-garijo, F. A. Martin, and G. Morata, Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in Drosophila, Development, vol.131, pp.5591-5598, 2004.

A. Perez-garijo, F. A. Martin, G. Struhl, and G. Morata, Dpp signaling and the induction of neoplastic tumors by caspase-inhibited apoptotic cells in Drosophila, Proc Natl Acad Sci U S A, vol.102, pp.17664-17669, 2005.

B. S. Wells, E. Yoshida, and L. A. Johnston, Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity, Curr Biol, vol.16, pp.1606-1615, 2006.

J. R. Huh, M. Guo, and B. A. Hay, Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role, Curr Biol, vol.14, pp.1262-1266, 2004.

B. Mollereau, A. Perez-garijo, A. Bergmann, M. Miura, and O. Gerlitz, Compensatory proliferation and apoptosis-induced proliferation: a need for clarification, Cell death and differentiation, vol.20, p.181, 2013.
URL : https://hal.archives-ouvertes.fr/ensl-00962316

S. C. Herrera, R. Martin, and G. Morata, Tissue homeostasis in the wing disc of Drosophila melanogaster: immediate response to massive damage during development, PLoS genetics, vol.9, p.1003446, 2013.