Effect and impact of mechanical ventilation in myotonic dystrophy type 1: a prospective cohort study - Université de Versailles Saint-Quentin-en-Yvelines Access content directly
Journal Articles Thorax Year : 2018

Effect and impact of mechanical ventilation in myotonic dystrophy type 1: a prospective cohort study

Abstract

Few studies have assessed the impact of home ventilation in patients with myotonic dystrophy type 1 (DM1) and no specific recommendations are available. We assessed the survival associated with category of home ventilation adherence of patients with DM1 followed up at a home ventilation unit using a Cox proportional hazards model. 218 patients were included; those who refused or delayed their acceptance of non-invasive ventilation were at higher risk for severe events (invasive ventilation or death) (P=0.03). Risk of death was associated with orthopnoea (HR 2.37; 95% CI 1.17 to 4.80; P<0.02) and adherence category (100 to 90% vs >75%: HR 3.26; 95% CI 1.32 to 8.04; P<0.03). Failure to use home ventilation as prescribed may be associated with increased mortality in patients with DM1.

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Health

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hal-04533881 , version 1 (05-04-2024)

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Ghilas Boussaïd, Hélène Prigent, Pascal Laforet, Jean-Claude Raphaël, Djillali Annane, et al.. Effect and impact of mechanical ventilation in myotonic dystrophy type 1: a prospective cohort study. Thorax, 2018, 73 (11), pp.1075-1078. ⟨10.1136/thoraxjnl-2017-210610⟩. ⟨hal-04533881⟩
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