Corticosteroids for COVID-19 - Université de Versailles Saint-Quentin-en-Yvelines Access content directly
Journal Articles Journal of Intensive Medicine Year : 2020

Corticosteroids for COVID-19

Abstract

Coronavirus disease 19 (COVID-19) is placing a major burden on healthcare, economy and social systems worldwide owing to its fast spread and unacceptably high death toll. The unprecedented research effort has established the role of a deregulated immune response to the severe acute respiratory syndrome coronavirus 2, resulting in systemic inflammation. After that, the immunomodulatory approach has been placed in the top list of the research agenda for COVID-19. Corticosteroids have been used for more than 70 years to modulate the immune response in a broad variety of diseases. These drugs have been shown to prevent and attenuate inflammation both in tissues and in circulation via non-genomic and genomic effects. At the bedside, numerous observational cohorts have been published in the past months and have been inconclusive. Randomized controlled trials with subsequent high quality meta-analyses have provided moderate to strong certainty for an increased chance of survival and relief from life supportive therapy with corticosteroids given at a dose of 6 mg per day dexamethasone or equivalent doses of hydrocortisone or methylprednisolone. The corticotherapy was not associated with an increased risk of bacterial infection or of delayed viral clearance. In daily practice, physicians may be encouraged to use corticosteroids when managing patients with COVID-19 requiring oxygen supplementation.
Fichier principal
Vignette du fichier
1-s2.0-S2667100X21000037-main.pdf (1.57 Mo) Télécharger le fichier
Origin Publisher files allowed on an open archive
Licence

Dates and versions

hal-04535256 , version 1 (06-04-2024)

Licence

Identifiers

Cite

Djillali Annane. Corticosteroids for COVID-19. Journal of Intensive Medicine, 2020, 1 (1), pp.14 - 25. ⟨10.1016/j.jointm.2021.01.002⟩. ⟨hal-04535256⟩
4 View
10 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More