Evolutionary conservation of Notch signaling inhibition by TMEM131L overexpression - Archive ouverte HAL Access content directly
Journal Articles Biochemical and Biophysical Research Communications Year : 2017

Evolutionary conservation of Notch signaling inhibition by TMEM131L overexpression

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Abstract

Human KIAA0922/TMEM131L encodes a transmembrane protein, TMEM131L, that regulates the canonical Wnt/b-catenin signaling pathway by eliciting the lysosome-dependent degradation of phosphorylated LRP6 co-receptor. Here, we use a heterospecific Drosophila transgenic model to examine the potential evolutionary conservation of TMEM131L function. Analysis of TMEM131L transgenic flies shows that TMEM131L interference with the Wnt pathway results primarily from a Notch-dependent decrease in Wingless production. Consistently, lentivirus-mediated overexpression of TMEM131L in human CD34 þ hematopoietic progenitor cells leads to decreased susceptibility to Notch1 ligation and defective commitment toward the T lineage. These results show that TMEM131L corresponds to an evolutionary conserved regulator of the Notch signaling pathway.
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hal-02975504 , version 1 (22-10-2020)

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Sebastien Szuplewski, Nesrine Maharzi, Elisabeth Nelson, Kutaiba Alhaj Hussen, Bernard Mignotte, et al.. Evolutionary conservation of Notch signaling inhibition by TMEM131L overexpression. Biochemical and Biophysical Research Communications, 2017, ⟨10.1016/j.bbrc.2017.03.123⟩. ⟨hal-02975504⟩
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