Despite the interest in (Zn, Fe, and Zr)-nanoscaled metal− organic frameworks (nanoMOFs) as intravenous drug nanocarriers, their most convenient oral administration has been almost unexplored. In this scenario, an uncharted Ti-nanoMOF is originally proposed here as an oral therapeutic agent, not as a drug delivery system but as an innovative and efficient oral detoxifying agent of the challenge and timeliness salicylate intoxication (e.g., aspirin). Thus, this orally robust and biosafe Ti-nanoMOF is the only porous nanomaterial, among the six tested MOFs, able to adsorb and retain aspirin under the whole gastrointestinal tract, overpassing the capabilities of the current treatment (i.e., activated charcoal). Further, the biodistribution and bioremoval of Ti-nanoMOF have been assessed, proving a bioprotective character with an intact and almost complete removal by feces.