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Journal Articles EMBO Journal Year : 1988

The Xenopus laevis mitochondrial protein mtDBP-C cooperatively folds the DNA in vitro

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Abstract

The binding of the Xenopus laevis mitochondrial protein mtDBP-C to DNA was studied by equilibrium density banding, agarose gel electrophoresis and electron microscopy. The results obtained show that the mtDBP-C binds cooperatively to DNA irrespective of whether the DNA is supercoiled, relaxed or linear and it induces the formation of superhelical turns locally leading to the formation of a highly folded structure. It appears that this protein could be involved in the compaction of DNA in the mitochondrial nucleoid.
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Dates and versions

hal-03038243 , version 1 (18-12-2020)

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  • HAL Id : hal-03038243 , version 1

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Bernard Mignotte, Etienne Delain, David Rickwood, Monique Barat-Gueride. The Xenopus laevis mitochondrial protein mtDBP-C cooperatively folds the DNA in vitro. EMBO Journal, 1988, 7 (12), pp.3873-3879. ⟨hal-03038243⟩
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