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Structural modifications induced by the mtDBP-C protein in the repfication origin of Xenopus laevis mitochondrial DNA

Abstract : The structure of the non-coding region of Xenopus laevis mitochondrial DNA has been studied by electron microscopy analysis of DNA molecules end-labelled with streptavidin-ferritin. We have shown that the effect of a protein modifying the shape of the DNA double-helix can be studied and precisely located by this method. It was found that the non-coding region contains curved segments and that the mitochondrial protein mtDBP-C preferentially enhances the curvature of the promoters-replication origin region. electron microscopy / DNA-binding pro, rein / mitochondrial DNA / DNA bending / DNA curvature
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https://hal.uvsq.fr/hal-03038255
Contributor : Bernard Mignotte <>
Submitted on : Friday, December 18, 2020 - 4:43:21 PM
Last modification on : Sunday, December 20, 2020 - 3:00:27 AM

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Bernard Mignotte, Bernard Theveny, B Revet. Structural modifications induced by the mtDBP-C protein in the repfication origin of Xenopus laevis mitochondrial DNA. Biochimie, Elsevier, 1990. ⟨hal-03038255⟩

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