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Apoptosis of cell lines conditionally immortalized by SV40 is not associated with a pattern of gene induction similar to that observed during thymocyte apoptosis

Abstract : Inactivation of SV40 large T antigen, in cells immortalized with conditional mutants, leads to activation of p53 and apoptosis. We have analyzed during this process the expression of genes induced by p53 or differentially expressed during apoptosis in other systems. We find an early induction of Waf1/Cip1. We also observed clusterin is induced late during the process and displays a high level of expression in non-apoptotic cells suggesting a protective role for clusterin. Other genes identified during thymocyte and lymphocyte apoptosis are not induced, showing that the pattern of gene induction is specific to the system studied.
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https://hal.uvsq.fr/hal-03038620
Contributor : Bernard Mignotte <>
Submitted on : Thursday, December 3, 2020 - 3:37:20 PM
Last modification on : Friday, January 22, 2021 - 4:42:15 PM
Long-term archiving on: : Thursday, March 4, 2021 - 7:25:36 PM

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Isabelle Gueńal, Bernard Mignotte. Apoptosis of cell lines conditionally immortalized by SV40 is not associated with a pattern of gene induction similar to that observed during thymocyte apoptosis. FEBS Letters, Wiley, 1995. ⟨hal-03038620⟩

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