Skip to Main content Skip to Navigation
Journal articles

Studies of specific gene induction during apoptosis of cell lines conditionally immortalized by SV40

Abstract : Inactivation of SV40 large T antigen, in cells immortalized with conditional mutants, leads to activation of p53 and apoptosis. We have analyzed during this process the expression of genes induced by p53 or differentially expressed during apoptosis in other systems. We find an early induction of Waf1/Cip1. We also observed clusterin is induced late during the process and displays a high level of expression in non-apoptotic cells suggesting a protective role for clusterin. Other genes identified during thymocyte and lymphocyte apoptosis are not induced, showing that the pattern of gene induction is specific to the system studied.
Document type :
Journal articles
Complete list of metadata

https://hal.uvsq.fr/hal-03038620
Contributor : Bernard Mignotte Connect in order to contact the contributor
Submitted on : Thursday, December 3, 2020 - 3:37:20 PM
Last modification on : Saturday, September 24, 2022 - 3:57:45 AM
Long-term archiving on: : Thursday, March 4, 2021 - 7:25:36 PM

File

texteFEBS95.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : hal-03038620, version 1

Citation

Isabelle Guénal, Bernard Mignotte. Studies of specific gene induction during apoptosis of cell lines conditionally immortalized by SV40. FEBS Letters, Wiley, 1995. ⟨hal-03038620v1⟩

Share

Metrics

Record views

917

Files downloads

6160