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Implication of mitochondria in apoptosis

Abstract : The induction phase of programmed cell death (PCD) or apoptosis is characterized by an extreme heterogeneity of potential PCDtriggering signal transduction pathways. During the subsequent effector phase, the numerous PCD-inducing stimuli converge into a few stereotypical pathways and cells pass a 'point of no return', thus becoming irreversibly committed to death. Evidence is accumulating that cytoplasmic structures, including mitochondria, participate in the critical effector stage and that alterations usually considered to define apoptosis, as nuclear chromatolysis and cytolysis, have to be ascribed to the late degradation phase. We and others have recently shown that nuclear features of apoptosis are preceded by alterations in mitochondrial function and structure. The importance of these alterations for the apoptotic process and also the possible link between, these observations, the permeability transition pore and the programmed cell death, are discussed.
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Contributor : Bernard Mignotte Connect in order to contact the contributor
Submitted on : Friday, December 18, 2020 - 3:29:13 PM
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  • HAL Id : hal-03038634, version 1



Patrice X Petit, Naoufal Zamzami, Jean-Luc Vayssière, Bernard Mignotte, Guido Kroemer, et al.. Implication of mitochondria in apoptosis. Molecular and Cellular Biochemistry, 1997, 174, pp.185-188. ⟨hal-03038634⟩



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