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Vaccine strategies against cystic fibrosis pathogens

Abstract : A great number of cystic fibrosis (CF) pathogens such as Pseudomonas aeruginosa, the Burkholderia cepacia and the Mycobacterium abscessus complex raised difficult therapeutic problems due to their intrinsic multiresistance to numerous antibiotics. Vaccine strategies represent one of the key weapons against these multi-resistant bacteria in a number of clinical settings like CF. Different strategies are considered in order to develop such vaccines, linked either to priming the host response, or by exploiting genomic data derived from the bacterium. Interestingly, virulence factors synthesized by various pathogens might serve as targets for vaccine development and have been, for example, evaluated in the context of CF.
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Contributor : Vincent LE MOIGNE Connect in order to contact the contributor
Submitted on : Tuesday, May 31, 2022 - 3:50:26 PM
Last modification on : Friday, October 14, 2022 - 9:11:57 AM


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Vincent Le Moigne, Jean-Louis Gaillard, Jean-Louis Herrmann. Vaccine strategies against cystic fibrosis pathogens. Human Vaccines & Immunotherapeutics, 2016, 12 (3), pp.751 - 756. ⟨10.1080/21645515.2015.1102810⟩. ⟨hal-03680920⟩



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