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Vaccine strategies against bacterial pathogens in cystic fibrosis patients

Abstract : A large number of cystic fibrosis pathogens such as bacteria of the Burkholderia cepacia complex, Pseudomonas aeruginosa, or Mycobacterium abscessus are associated with complex therapeutic problems due to their inherent resistance to antibiotics. No vaccine is currently available against those pathogens. Vaccines are therefore crucial to combat these multidrug-resistant bacteria in specific clinical situations including cystic fibrosis. Various strategies may be considered to develop these vaccines. Similar virulence factors are expressed during the infection with various pathogens; they could thus be used as antigen to assess cross-protection. Many clinical trials are currently being conducted to try and develop a prophylactic treatment for patients presenting with cystic fibrosis.
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https://hal.uvsq.fr/hal-03685287
Contributor : Vincent LE MOIGNE Connect in order to contact the contributor
Submitted on : Thursday, June 2, 2022 - 8:44:26 AM
Last modification on : Tuesday, June 14, 2022 - 5:24:50 PM

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Vincent Le Moigne, Jean-Louis Gaillard, Jean-Louis Herrmann. Vaccine strategies against bacterial pathogens in cystic fibrosis patients. Médecine et Maladies Infectieuses, Elsevier Masson, 2016, 46 (1), pp.4-9. ⟨10.1016/j.medmal.2015.11.013⟩. ⟨hal-03685287⟩

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