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Immune Response to Chlamydophila abortus POMP91B Protein in the Context of Different Pathogen Associated Molecular Patterns (PAMP); Role of Antigen in the Orientation of Immune Response

Abstract : In a previous study, we used bacterial flagellin to deliver antigens such as p27 of Mycobacterium tuberculosis to a host immune system and obtained a potent Th1 response compared to those obtained with Freund's adjuvant and DNA immunization. In the current study, using a POMP91B antigen of Chlamydophila abortus, a human and animal pathogen, as a model, we found that this antigen is unable to promote Th1 response. However, this antigen, unlike others, was able to induce a good Th2 response and IL-4 production after immunization by recombinant protein in Freund's adjuvant or in phosphate buffered saline. Our results suggest that immune response is not only dependent on the immunization adjuvant, but also dependent on the nature of antigen used.
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https://hal.uvsq.fr/hal-03712031
Contributor : Vincent LE MOIGNE Connect in order to contact the contributor
Submitted on : Saturday, July 2, 2022 - 6:05:08 AM
Last modification on : Wednesday, July 6, 2022 - 3:04:06 AM
Long-term archiving on: : Monday, October 3, 2022 - 6:23:45 PM

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Vincent Le Moigne, Georges Robreau, Wahib Mahana. Immune Response to Chlamydophila abortus POMP91B Protein in the Context of Different Pathogen Associated Molecular Patterns (PAMP); Role of Antigen in the Orientation of Immune Response. Toxins, 2009, 1 (2), pp.59 - 73. ⟨10.3390/toxins1020059⟩. ⟨hal-03712031⟩

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