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Journal Articles Acute and Critical Care Year : 2022

Clinical characteristics and outcomes of critically ill COVID-19 patients in Sfax, Tunisia

Kamilia Chtara
  • Function : Author
Malek Hafdhi
  • Function : Author
Olfa Turki
  • Function : Author
Najeh Baccouche
  • Function : Author
Rania Ammar
  • Function : Author
Nozha Kallel
  • Function : Author
Majdi Hsairi
  • Function : Author
Olfa Chakroun-Walha
  • Function : Author
Chokri Ben Hamida
  • Function : Author
Hedi Chelly
  • Function : Author
Khaiereddine Ben Mahfoudh
  • Function : Author
Abelhamid Karoui
  • Function : Author
Hela Karray
  • Function : Author
Noureddine Rekik
  • Function : Author
Mounir Bouaziz
  • Function : Author

Abstract

Background: Africa, like the rest of the world, has been impacted by the coronavirus disease 2019 (COVID-19) pandemic. However, only a few studies covering this subject in Africa have been published. Methods: We conducted a retrospective study of critically ill adult COVID-19 patients—all of whom had a confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection—admitted to the intensive care unit (ICU) of Habib Bourguiba University Hospital (Sfax, Tunisia). Results: A total of 96 patients were admitted into our ICU for respiratory distress due to COVID-19 infection. Mean age was 62.4±12.8 years and median age was 64 years. Mean PaO2/FiO2 ratio was 105±60 and ≤300 in all cases but one. Oxygen support was required for all patients (100%) and invasive mechanical ventilation for 38 (40%). Prone positioning was applied in 37 patients (38.5%). Within the study period, 47 of the 96 patients died (49%). Multivariate analysis showed that the factors associated with poor outcome were the development of acute renal failure (odds ratio [OR], 6.7), the use of mechanical ventilation (OR, 5.8), and serum cholinesterase (SChE) activity lower than 5,000 UI/L (OR, 5.9). Conclusions: In this retrospective cohort study of critically ill patients admitted to the ICU in Sfax, Tunisia, for acute respiratory failure following COVID-19 infection, the mortality rate was high. The development of acute renal failure, the use of mechanical ventilation, and SChE activity lower than 5000 UI/L were associated with a poor outcome.

Dates and versions

hal-04397029 , version 1 (16-01-2024)

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Mabrouk Bahloul, Sana Kharrat, Kamilia Chtara, Malek Hafdhi, Olfa Turki, et al.. Clinical characteristics and outcomes of critically ill COVID-19 patients in Sfax, Tunisia. Acute and Critical Care, 2022, 37 (1), pp.84-93. ⟨10.4266/acc.2021.00129⟩. ⟨hal-04397029⟩
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