The Role of Neutrophils in Spondyloarthritis: A Journey across the Spectrum of Disease Manifestations - Université de Versailles Saint-Quentin-en-Yvelines Access content directly
Journal Articles International Journal of Molecular Sciences Year : 2023

The Role of Neutrophils in Spondyloarthritis: A Journey across the Spectrum of Disease Manifestations

Lavinia Agra Coletto
Chiara Rizzo
  • Function : Author
Giuliana Guggino
  • Function : Author
Roberto Caporali
  • Function : Author
Stefano Alivernini
  • Function : Author

Abstract

Spondyloarthritis (SpA) contemplates the inflammatory involvement of the musculoskeletal system, gut, skin, and eyes, delineating heterogeneous diseases with a common pathogenetic background. In the framework of innate and adaptive immune disruption in SpA, neutrophils are arising, across different clinical domains, as pivotal cells crucial in orchestrating the pro-inflammatory response, both at systemic and tissue levels. It has been suggested they act as key players along multiple stages of disease trajectory fueling type 3 immunity, with a significant impact in the initiation and amplification of inflammation as well as in structural damage occurrence, typical of long-standing disease. The aim of our review is to focus on neutrophils’ role within the spectrum of SpA, dissecting their functions and abnormalities in each of the relevant disease domains to understand their rising appeal as potential biomarkers and therapeutic targets.
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hal-04551346 , version 1 (18-04-2024)

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Lavinia Agra Coletto, Chiara Rizzo, Giuliana Guggino, Roberto Caporali, Stefano Alivernini, et al.. The Role of Neutrophils in Spondyloarthritis: A Journey across the Spectrum of Disease Manifestations. International Journal of Molecular Sciences, 2023, 24 (4), pp.4108. ⟨10.3390/ijms24044108⟩. ⟨hal-04551346⟩
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