Vinylic Trifluoromethylselenolation via Pd‐Catalyzed C−H Activation - Archive ouverte HAL Access content directly
Journal Articles Chemistry - A European Journal Year : 2022

Vinylic Trifluoromethylselenolation via Pd‐Catalyzed C−H Activation

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Abstract

Trifluorometylselenolation via C−H activation is barely described in literature. In particular, no such vinylic functionalization has been yet described. Herein, a palladium-catalyzed trifluoromethylselenolation of vinylic C−H bonds is described. The 5-methoxy-8-aminoquinoline has been used as auxiliary directing group to perform this reaction. The reaction gives excellent yields with α-substituted compounds whatever the substituents and a microwave activation can be used to accelerate the reaction. With β-substituted substrates lower yields, but still satisfactory, are obtained. This methodology was also successfully extended to other fluoroalkylselenyl groups.
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Dates and versions

hal-03784203 , version 1 (22-09-2022)

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Arnaud de Zordo-Banliat, Kevin Grollier, Jordan Vigier, Erwann Jeanneau, Guillaume Dagousset, et al.. Vinylic Trifluoromethylselenolation via Pd‐Catalyzed C−H Activation. Chemistry - A European Journal, In press, ⟨10.1002/chem.202202299⟩. ⟨hal-03784203⟩
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