Vinylic Trifluoromethylselenolation via Pd‐Catalyzed C−H Activation
Abstract
Trifluorometylselenolation via C−H activation is barely described in literature. In particular, no such vinylic functionalization has been yet described. Herein, a palladium-catalyzed trifluoromethylselenolation of vinylic C−H bonds is described. The 5-methoxy-8-aminoquinoline has been used as auxiliary directing group to perform this reaction. The reaction gives excellent yields with α-substituted compounds whatever the substituents and a microwave activation can be used to accelerate the reaction. With β-substituted substrates lower yields, but still satisfactory, are obtained. This methodology was also successfully extended to other fluoroalkylselenyl groups.
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Chemistry A European J - 2022 - Zordo‐Banliat - Vinylic Trifluoromethylselenolation via Pd‐Catalyzed C H Activation-1.pdf (3.54 Mo)
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