A catalog of numerical centrosome defects in epithelial ovarian cancers - Université de Versailles Saint-Quentin-en-Yvelines Access content directly
Journal Articles EMBO Molecular Medicine Year : 2022

A catalog of numerical centrosome defects in epithelial ovarian cancers

Anthony Simon
Aurélie Herbette
Jorge Barbazan
Carlos Pérez-González
Camille Cosson
Bassirou Mboup
Aurélien Latouche
Yann Kieffer
Anne‐sophie Macé
Pierre Gestraud
Guillaume Bataillon
Didier Meseure
Odette Mariani
Anne Vincent-Salomon
Marc‐henri Stern
Fatima Mechta-Grigoriou
Sergio Roman Roman
Danijela Matic Vignjevic
Oumou Goundiam
Renata Basto

Abstract

Centrosome amplification, the presence of more than two centrosomes in a cell is a common feature of most human cancer cell lines. However, little is known about centrosome numbers in human cancers and whether amplification or other numerical aberrations are frequently present. To address this question, we have analyzed a large cohort of primary human epithelial ovarian cancers (EOCs) from 100 patients. We found that rigorous quantitation of centrosome number in tumor samples was extremely challenging due to tumor heterogeneity and extensive tissue disorganization. Interestingly, even if centrosome clusters could be identified, the incidence of centrosome amplification was not comparable to what has been described in cultured cancer cells. Surprisingly, centrosome loss events where a few or many nuclei were not associated with centrosomes were clearly noticed and overall more frequent than centrosome amplification. Our findings highlight the difficulty of characterizing centrosome numbers in human tumors, while revealing a novel paradigm of centrosome number defects in EOCs.
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hal-03838718 , version 1 (03-11-2022)

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Jean‐philippe Morretton, Anthony Simon, Aurélie Herbette, Jorge Barbazan, Carlos Pérez-González, et al.. A catalog of numerical centrosome defects in epithelial ovarian cancers. EMBO Molecular Medicine, 2022, 14 (9), ⟨10.15252/emmm.202215670⟩. ⟨hal-03838718⟩
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