A catalog of numerical centrosome defects in epithelial ovarian cancers
Abstract
Centrosome amplification, the presence of more than two centrosomes in a cell is a common feature of most human cancer cell
lines. However, little is known about centrosome numbers in
human cancers and whether amplification or other numerical
aberrations are frequently present. To address this question, we
have analyzed a large cohort of primary human epithelial ovarian
cancers (EOCs) from 100 patients. We found that rigorous quantitation of centrosome number in tumor samples was extremely
challenging due to tumor heterogeneity and extensive tissue disorganization. Interestingly, even if centrosome clusters could be
identified, the incidence of centrosome amplification was not comparable to what has been described in cultured cancer cells. Surprisingly, centrosome loss events where a few or many nuclei were
not associated with centrosomes were clearly noticed and overall
more frequent than centrosome amplification. Our findings highlight the difficulty of characterizing centrosome numbers in
human tumors, while revealing a novel paradigm of centrosome
number defects in EOCs.
Domains
Life Sciences [q-bio]
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