DREAM a little dREAM of DRM: Model organisms and conservation of DREAM-like complexes - Université de Versailles Saint-Quentin-en-Yvelines Access content directly
Journal Articles BioEssays Year : 2023

DREAM a little dREAM of DRM: Model organisms and conservation of DREAM-like complexes

Abstract

DREAM complexes are transcriptional regulators that control the expression of hundreds to thousands of target genes involved in the cell cycle, quiescence, differentiation, and apoptosis. These complexes contain many subunits that can vary according to the considered target genes. Depending on their composition and the nature of the partners they recruit, DREAM complexes control gene expression through diverse mechanisms, including chromatin remodeling, transcription cofactor and factor recruitment at various genomic binding sites. This complexity is particularly high in mammals. Since the discovery of the first dREAM complex (drosophila Rb, E2F, and Myb) in Drosophila melanogaster, model organisms such as Caenorhabditis elegans, and plants allowed a deeper understanding of the processes regulated by DREAMlike complexes. Here, we review the conservation of these complexes. We discuss the contribution of model organisms to the study of DREAM-mediated transcriptional regulatory mechanisms and their relevance in characterizing novel activities of DREAM complexes.
Fichier principal
Vignette du fichier
BioEssays - 2023 - Hoareau - DREAM a little dREAM of DRM Model organisms and conservation of DREAM‐like complexes.pdf (704.52 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Licence : CC BY NC ND - Attribution - NonCommercial - NoDerivatives

Dates and versions

hal-04329736 , version 1 (07-12-2023)

Identifiers

Cite

Marion Hoareau, Aurore Rincheval-Arnold, Sébastien Gaumer, Isabelle Guénal. DREAM a little dREAM of DRM: Model organisms and conservation of DREAM-like complexes: Model organisms uncover the mechanisms of DREAM-mediated transcription regulation. BioEssays, 2023, 46 (2), ⟨10.1002/bies.202300125⟩. ⟨hal-04329736⟩
72 View
37 Download

Altmetric

Share

Gmail Facebook X LinkedIn More