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Article Dans Une Revue Annals of the Rheumatic Diseases Année : 2023

The provisional OMERACT ultrasonography score for giant cell arteritis

Christian Dejaco
Cristina Ponte
Sara Monti
Davide Rozza
  • Fonction : Auteur
Carlo Alberto Scirè
Lene Terslev
  • Fonction : Auteur
George Bruyn
Dennis Boumans
Wolfgang Hartung
  • Fonction : Auteur
Alojzija Hočevar
Marcin Milchert
Uffe Møller Døhn
  • Fonction : Auteur
Chetan Mukhtyar
Markus Aschwanden
  • Fonction : Auteur
Philipp Bosch
Dario Camellino
Stavros Chrysidis
Giovanni Ciancio
  • Fonction : Auteur
Thomas Daikeler
  • Fonction : Auteur
Bhaskar Dasgupta
  • Fonction : Auteur
Eugenio de Miguel
Andreas Diamantopoulos
  • Fonction : Auteur
Christina Duftner
Ana Agueda
  • Fonction : Auteur
Ulrich Fredberg
  • Fonction : Auteur
Petra Hanova
Ib Tønder Hansen
  • Fonction : Auteur
Ellen-Margrethe Hauge
  • Fonction : Auteur
Annamaria Iagnocco
Nevsun Inanc
Aaron Juche
  • Fonction : Auteur
Rositsa Karalilova
Toshio Kawamoto
  • Fonction : Auteur
Kresten Krarup Keller
Helen Isobel Keen
  • Fonction : Auteur
Tanaz Kermani
Minna Kohler
  • Fonction : Auteur
Matthew Koster
Raashid Ahmed Luqmani
  • Fonction : Auteur
Pierluigi Macchioni
  • Fonction : Auteur
Sarah Louise Mackie
  • Fonction : Auteur
Esperanza Naredo
Berit Dalsgaard Nielsen
  • Fonction : Auteur
Michihiro Ogasawara
  • Fonction : Auteur
Carlos Pineda
Valentin Sebastian Schäfer
Luca Seitz
Alessandro Tomelleri
Karina Torralba
Kornelis van der Geest
Kenneth Warrington
  • Fonction : Auteur
Wolfgang Schmidt

Résumé

Objectives To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. Methods The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima–media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24. Results Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72–0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from −1.19 to −2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corr coeff 0.37–0.48). Conclusion We developed a provisional OGUS for potential use in clinical trials.

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Dates et versions

hal-04552292 , version 1 (19-04-2024)

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Copyright (Tous droits réservés)

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Christian Dejaco, Cristina Ponte, Sara Monti, Davide Rozza, Carlo Alberto Scirè, et al.. The provisional OMERACT ultrasonography score for giant cell arteritis. Annals of the Rheumatic Diseases, 2023, 82 (4), pp.556-564. ⟨10.1136/ard-2022-223367⟩. ⟨hal-04552292⟩
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