The provisional OMERACT ultrasonography score for giant cell arteritis - Université de Versailles Saint-Quentin-en-Yvelines Access content directly
Journal Articles Annals of the Rheumatic Diseases Year : 2023

The provisional OMERACT ultrasonography score for giant cell arteritis

Christian Dejaco
Cristina Ponte
Sara Monti
Davide Rozza
  • Function : Author
Carlo Alberto Scirè
Lene Terslev
  • Function : Author
George Bruyn
Dennis Boumans
Wolfgang Hartung
  • Function : Author
Alojzija Hočevar
Marcin Milchert
Uffe Møller Døhn
  • Function : Author
Chetan Mukhtyar
Markus Aschwanden
  • Function : Author
Philipp Bosch
Dario Camellino
Stavros Chrysidis
Giovanni Ciancio
  • Function : Author
Thomas Daikeler
  • Function : Author
Bhaskar Dasgupta
  • Function : Author
Eugenio de Miguel
Andreas Diamantopoulos
  • Function : Author
Christina Duftner
Ana Agueda
  • Function : Author
Ulrich Fredberg
  • Function : Author
Petra Hanova
Ib Tønder Hansen
  • Function : Author
Ellen-Margrethe Hauge
  • Function : Author
Annamaria Iagnocco
Nevsun Inanc
Aaron Juche
  • Function : Author
Rositsa Karalilova
Toshio Kawamoto
  • Function : Author
Kresten Krarup Keller
Helen Isobel Keen
  • Function : Author
Tanaz Kermani
Minna Kohler
  • Function : Author
Matthew Koster
Raashid Ahmed Luqmani
  • Function : Author
Pierluigi Macchioni
  • Function : Author
Sarah Louise Mackie
  • Function : Author
Esperanza Naredo
Berit Dalsgaard Nielsen
  • Function : Author
Michihiro Ogasawara
  • Function : Author
Carlos Pineda
Valentin Sebastian Schäfer
Luca Seitz
Alessandro Tomelleri
Karina Torralba
Kornelis van der Geest
Kenneth Warrington
  • Function : Author
Wolfgang Schmidt


Objectives To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. Methods The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima–media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24. Results Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72–0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from −1.19 to −2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corr coeff 0.37–0.48). Conclusion We developed a provisional OGUS for potential use in clinical trials.



Dates and versions

hal-04552292 , version 1 (19-04-2024)





Christian Dejaco, Cristina Ponte, Sara Monti, Davide Rozza, Carlo Alberto Scirè, et al.. The provisional OMERACT ultrasonography score for giant cell arteritis. Annals of the Rheumatic Diseases, 2023, 82 (4), pp.556-564. ⟨10.1136/ard-2022-223367⟩. ⟨hal-04552292⟩
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